Discussing the relationships between homoparenthood and health. / Problematizando as relações entre homoparentalidade e saúde.

The present article aims to bridge the gaps or deepen the debate to discuss the relationship between homoparenthood and health. This essay is anchored in specific literature. We seek to work on the following questions throughout the text: (i) How is the central theme of this discussion historically outlined? (ii) How does homoparenthood appear in scientific health production in general? (iii) What sociopolitical dimensions emerge around homoparenthood-health relationships? and (iv) What are the limitations and possibilities for exercising reproductive rights between same-sex couples? Among the conclusions, we underscore the challenge of facing the strangeness of homoparenthood against the idea of the so-called called "normal" family based on heteronormative logic. Even in countries with some legal apparatus assuring the rights to homoparental families, their members suffer prejudice, discrimination, and violence.

Buscando preencher lacunas e/ou aprofundar o debate, o artigo objetiva problematizar aspectos que envolvem as relações entre homoparentalidade e saúde. O desenho metodológico é o de ensaio, ancorado em literatura específica. Ao longo do texto procura-se trabalhar as seguintes questões: (i) Como se esboça historicamente a temática central desta discussão? (ii) Como se afigura a homoparentalidade no campo da produção científica da saúde em geral? (iii) Quais dimensões sociopolíticas emergem em torno das relações homoparentalidade-saúde? e (iv) Quais são os limites e as possibilidades para o exercício dos direitos reprodutivos entre casais homoafetivos? Dentre as conclusões, destaca-se o desafio de se enfrentar o estranhamento da temática homoparentalidade para a ideia da família denominada de "normal", configurada a partir da lógica heteronormativa. Mesmo nos países em que há algum aparato jurídico que garanta direitos às famílias homoparentais, seus integrantes são alvo de preconceitos, discriminações e violências.

Digital activism about gay fatherhood on Instagram: male homoparenting in the picture. / Ativismo digital sobre paternidade gay no Instagram: a homoparentalidade masculina em cena.

In contemporary Brazil, the number of male fathers taking care of their sons and daughters and the initiatives to produce content about fatherhood on Instagram have been significant. This article aims to analyze the concepts that support the digital activism of homoparenting on Instagram, based on gender studies with men. To this end, a qualitative study was conducted using the life narrative method in a digital environment. The results were analyzed and divided into the following sections: parenting project, personal experience of fatherhood, articulation with LGBT political agenda when parenthood becomes a "business", and haters, criticism, and adverse reactions. It was concluded that the reflection on the experience of fatherhood/masculinity itself is crossed by the social marker of the difference in sexual orientation and the activism for rights that sustain content production. Thus, the uniqueness of each fatherhood is highlighted since the fact of being gay constructs the fatherhood experience for each man. Despite the initiatives brought forth in this study, changes are still in progress, as rights activism coexists with the advancement of conservative forces, which limit the expressions of sexual and gender otherness.

No Brasil contemporâneo tem sido expressivo tanto o número de homens-pais assumindo o cuidado de seus filhos e filhas, quanto das iniciativas de produção de conteúdo sobre paternidades no Instagram. Este artigo visa analisar as concepções que sustentam o ativismo digital da homoparentalidade no Instagram, a partir dos estudos de gênero com homens. Para tal, realizou-se um estudo qualitativo em ambiência digital, utilizando o método das narrativas de vida. Os resultados foram analisados e divididos nas seguintes seções: projeto de parentalidade; experiência pessoal de paternidade; articulação de agenda política LGBT; quando a paternidade vira um "negócio"; e haters, críticas e reações negativas. Conclui-se que a reflexão sobre a própria experiência de paternidade/masculinidade, atravessada pelo marcador social da diferença orientação sexual e o ativismo por direitos que sustentam a produção de conteúdo. Assim, ressalta-se a singularidade de cada paternidade, pois o fato de ser gay constrói a experiência de paternidade particular para cada homem. Apesar das iniciativas expostas, mudanças ainda são incipientes, visto que o ativismo por direitos coexiste com o avanço de forças conservadoras, que limitam as expressões das alteridades sexuais e de gênero.

Phylogenomics of Dengue Virus Isolates Causing Dengue Outbreak, São Tomé and Príncipe, 2022.

We determined that the dengue outbreak in São Tomé and Príncipe during 2022 was caused by dengue virus serotype 3 genotype III. Phylogenomic analyses showed that the outbreak strain was closely related to the newly identified GIII-American-II lineage and that the virus probably was introduced from the Americas.

Protracted neuronal recruitment in the temporal lobes of young children.

The temporal lobe of the human brain contains the entorhinal cortex (EC). This region of the brain is a highly interconnected integrative hub for sensory and spatial information; it also has a key role in episodic memory formation and is the main source of cortical hippocampal inputs1-4. The human EC continues to develop during childhood5, but neurogenesis and neuronal migration to the EC are widely considered to be complete by birth. Here we show that the human temporal lobe contains many young neurons migrating into the postnatal EC and adjacent regions, with a large tangential stream persisting until the age of around one year and radial dispersal continuing until around two to three years of age. By contrast, we found no equivalent postnatal migration in rhesus macaques (Macaca mulatta). Immunostaining and single-nucleus RNA sequencing of ganglionic eminence germinal zones, the EC stream and the postnatal EC revealed that most migrating cells in the EC stream are derived from the caudal ganglionic eminence and become LAMP5+RELN+ inhibitory interneurons. These late-arriving interneurons could continue to shape the processing of sensory and spatial information well into postnatal life, when children are actively interacting with their environment. The EC is one of the first regions of the brain to be affected in Alzheimer's disease, and previous work has linked cognitive decline to the loss of LAMP5+RELN+ cells6,7. Our investigation reveals that many of these cells arrive in the EC through a major postnatal migratory stream in early childhood.

The Decision-Making of High-Level Volleyball Setters in the 2021-2022 Volleyball Men's Superliga: Does the Opponent Matter?

Our primary objective in this study was to investigate the offensive strategies employed in the attack phase of men's volleyball, specifically focusing on side-out as stratified by the type of confrontation that was determined by the opponent's team performance. We analyzed 5524 attacking actions during 22 games of the 12 teams that participated in the Volleyball Men's Superliga (season 2021-2022). Based on their final rankings in the championship, we classified these teams into three tiers: high-performance, intermediate-performance, and low-performance. Subsequently, we examined the dynamics of these matches using Social Network Analysis. We found that the opponent teams' performance levels did not influence the game dynamics. Notably, the eigenvector values were prominently higher for Attack Zones 2 and 4, wherein the middle-blocker jumped to attack close to the setter across all networks. Thus, setters opted for traditional and low-risk strategies to minimize errors, disregarding available information about the skill level of the opposing team, making their offensive tactics predictable.

Inter e intra-variability of the best ranked teams: A network analysis in male high-level volleyball.

The present research objective was to analyze the offensive phase from Complex I in high-level male volleyball teams in a macro- and micro-level view, through the inter e intra-team variability analysis of eight best teams of the 2018 Men's Volleyball World Championship over the social network analysis and eigenvector centrality. The sample consisted of 22 matches and 2,743 offensive actions, resulting in 8 sub-networks with 368 nodes and 6221 edges. The results showed from macro view the variables that presented highest centrality values were Attack Zone 4 (range 0.56-0.90), Attack Tempo 2 (0.65-0.87), Power Attack (0.62-0.94), No Touch Block (0.61-1), Attack Effect Continuity (0.59-0.94), and Middle Blocker Centralized (0.60-0.95). In a micro view, Reception Effect, Play Position, Reception Zone, and Block Composition showed high variability in each sub-network. The intra- and inter-team variability presented the importance of to respect each team idiosyncrasies and to consider the different approaches to the game and success.

Luto e paternidade: ressignificações da experiência paterna após a perda de um(a) filho(a) / Bereavement and paternity: resignifications of the paternal experience after losing a child / Luto y paternidad: resignificaciones de la experiencia paterna después de la pérdida de un(a) hijo(a)

O estudo baseia-se em pesquisa qualitativa de referencial socioantropológico, cujo objetivo foi compreender as ressignificações da paternidade diante da perda precoce de um filho. Sete homens foram entrevistados em ambientes digitais. Da análise pelo método de interpretação de sentidos, emergiram as categorias: representações sobre a paternidade; a experiência do luto; e ressignificações da paternidade. Os resultados apontaram que: 1) muitas representações paternas remeteram ao processo de tornar-se pai e à dedicação aos filhos; 2) evidenciaram-se particularidades do luto paterno, com destaque aos processos de despedida e às repercussões de apoio social; 3) as ressignificações abarcaram desde mudanças pessoais a iniciativas de mobilização pública. Os mandatos culturais masculinos incidem na invisibilização social do luto paterno. Assim, diante da lacuna existente no tema da Saúde Coletiva, busca-se trazer contribuições para a atenção aos pais enlutados.(AU)

We conducted a qualitative socio-anthropological study with the aim of understanding resignifications of paternity in the face of the loss of a child. Online interviews were conducted with seven men. We performed an analysis of the data using the interpretation of meanings method, resulting in the identification of the following categories: representations of paternity; the experience of grieving; and resignifications of paternity. The results revealed the following: 1) that many paternal representations alluded to the process of becoming a father and dedication to children; 2) the particularities of paternal grieving, highlighting the process of saying goodbye and the effects of social support; 3) that resignifications encompassed a range of aspects from personal change to public mobilization initiatives. Cultural norms of masculinity result in the social invisibilization of paternal grieving. Given the current lack of research on this topic in the field of public health, this study seeks to make contributions to the care of bereaved parents.(AU)

El estudio se basa en una investigación cualitativa de referencial socioantropológico cuyo objetivo fue comprender las resignificaciones de la paternidad ante la pérdida precoz de un hijo. Se entrevistaron siete hombres en ambientes digitales. Del análisis por el método de interpretación de sentidos, surgieron las categorías: representaciones sobre la paternidad, la experiencia de luto y resignificaciones de la paternidad. Los resultados señalaron que: 1) muchas representaciones paternas remitieron al proceso de convertirse en padre y de la dedicación a los hijos; 2) quedaron en evidencia particularidades del luto paterno, con destaque para los procesos de despedida y las repercusiones de apoyo social; 3) las resignificaciones abarcaron desde cambios personales a iniciativas de movilización pública. Los mandatos culturales masculinos inciden en la invisibilización social del luto paterno. Por lo tanto, ante la laguna existente sobre el tema en la Salud Colectiva, se busca brindar contribuciones para la atención a los padres enlutados.(AU)

"Aqui na favela, nada parou": percepção da pandemia de COVID-19 por homens jovens do Complexo da Maré, RJ, Brasil / "Here in the favela, nothing stopped": perception of the COVID-19 pandemics by young men from Complexo da Maré, RJ, Brazil

Resumo Este artigo discute as percepções de homens jovens moradores do Complexo da Maré, no Rio de Janeiro, sobre a pandemia de COVID-19 e as práticas de prevenção adotadas. Os dados foram coletados a partir de entrevistas semiestruturadas com homens entre 18 e 29 anos, obtidas no final de 2022, analisadas a partir da análise de conteúdo temática. Os resultados apontam adesão parcial dos jovens às práticas de prevenção preconizadas, com pouco distanciamento social, mas um alto índice de vacinação e resistência a discursos negacionistas, apesar de descreverem a favela como um ambiente pouco atento à pandemia. Fatores como escolaridade e fragilidade dos contratos de trabalho foram preponderantes nas estratégias de prevenção. A internet se destaca como a principal fonte de informação acessada por essa população e pode ser estratégica para a comunicação e educação em saúde de homens jovens no futuro.

Abstract This article discusses the perceptions of young men living in Complexo da Maré, Rio de Janeiro, Brazil, regarding the COVID-19 pandemic and the adoption of prevention techniques. Data were collected from semi-structured interviews with men between 18 and 29 years of age, conducted at the end of 2022, and analyzed using thematic content analysis. The results point to a partial adherence of young people to recommended prevention practices, with low social distancing, but a high vaccination rate and a resistance to negationist discourses, despite describing the favela as an environment that paid little attention to the pandemic. Factors, such as education and the fragility of employment contracts, were predominant in prevention strategies. The internet is the primary source of information accessed by this population and can be strategic for future health communication and education with young men.

A construção de políticas de saúde para as populações LGBT no Brasil: perspectivas históricas e desafios contemporâneos / Construction of LGBT health policies in Brazil: a historical perspective and contemporary challenges

Resumo Este ensaio procura produzir memórias sobre os percursos da construção de políticas de saúde para lésbicas, gays, bissexuais, travestis e transexuais (LGBT) no Brasil, a partir da noção de política sexual. Com base na construção de uma linha do tempo que tem por ponto de partida a criação do Sistema Único de Saúde, o artigo apresenta: as primeiras produções de cuidados em saúde a partir da epidemia de Aids nos anos 1990; como a saúde se torna objeto de políticas públicas, fruto do diálogo governamental com o movimento social organizado, tendo como referência a perspectiva dos direitos humanos e da produção de cidadanização para pessoas dissidentes da cisheteronorma; e por fim, a abordagem de saúde integral como premissa da política de saúde LGBT. Em um momento de avanços de forças conservadoras e de desmonte de direitos, são apontados os desafios atuais para a construção do cuidado integral em saúde que leve em consideração a diversidade sexual e de gênero.

Abstract This essay presents a timeline of the construction of health policies for lesbians, gays, bisexuals, transvestites and transsexuals (LGBT) in Brazil drawing on the concepts of sexual politics. Beginning with the creation of the Unified Health System, we outline the first health care policies developed in response to the AIDS epidemic in the 1990s. We then go on to show how, the fruit of dialogue between the government and the gay rights movement, LGBT health became the object of public policies focusing on human rights, comprehensive care, and strengthening the citizenship for people who deviate from hetero-cis-normativity. Against the backdrop of the rising tide of conservatism and dismantling of progress on LGBT rights, we highlight current challenges for achieving comprehensive health care that takes into account sexual and gender diversity.

Construction of LGBT health policies in Brazil: a historical perspective and contemporary challenges. / A construção de políticas de saúde para as populações LGBT no Brasil: perspectivas históricas e desafios contemporâneos.

This essay presents a timeline of the construction of health policies for lesbians, gays, bisexuals, transvestites and transsexuals (LGBT) in Brazil drawing on the concepts of sexual politics. Beginning with the creation of the Unified Health System, we outline the first health care policies developed in response to the AIDS epidemic in the 1990s. We then go on to show how, the fruit of dialogue between the government and the gay rights movement, LGBT health became the object of public policies focusing on human rights, comprehensive care, and strengthening the citizenship for people who deviate from hetero-cis-normativity. Against the backdrop of the rising tide of conservatism and dismantling of progress on LGBT rights, we highlight current challenges for achieving comprehensive health care that takes into account sexual and gender diversity.

Este ensaio procura produzir memórias sobre os percursos da construção de políticas de saúde para lésbicas, gays, bissexuais, travestis e transexuais (LGBT) no Brasil, a partir da noção de política sexual. Com base na construção de uma linha do tempo que tem por ponto de partida a criação do Sistema Único de Saúde, o artigo apresenta: as primeiras produções de cuidados em saúde a partir da epidemia de Aids nos anos 1990; como a saúde se torna objeto de políticas públicas, fruto do diálogo governamental com o movimento social organizado, tendo como referência a perspectiva dos direitos humanos e da produção de cidadanização para pessoas dissidentes da cisheteronorma; e por fim, a abordagem de saúde integral como premissa da política de saúde LGBT. Em um momento de avanços de forças conservadoras e de desmonte de direitos, são apontados os desafios atuais para a construção do cuidado integral em saúde que leve em consideração a diversidade sexual e de gênero.

An integrated assessment to reconstruct the history of changes influenced by multiple anthropogenic activities (City of Fortaleza, Ceará, Brazil).

In this study, the multi-marker approach was used for the first time with a highly urbanized lake located in the city of Fortaleza, Brazil, to provide a comprehensive view of temporal trends in sources of pollutants and evaluate the relation between the influence of anthropogenic activities and socioeconomic development. Total concentrations of the markers analyzed ranged from 21.0 to 103.8 ng g-1, 450.2 to 2390.2 ng g-1, and 233.8 to 9827.3 ng g-1 for ∑PAHs, ∑n-alk, and ∑sterols, respectively. Concentrations and patterns of PAH, AH, and sterol ratio distribution changed over time and may be associated with different episodes in the history of the city of Fortaleza. The marker ratio distribution in the sediment core revealed an overlap of natural and anthropogenic sources, with degraded oil, biogenic inputs, pyrogenic processes, and fecal contamination from humans and animals in the past changing to petroleum fossil inputs and high contamination from sewage in the present day. The distribution of markers and the chronological history of Fortaleza revealed two distinct periods related to human activities during the development of the city. In the first period (prior to the 1950s), the main human activities were animal breeding and the use of biomass for domestic activities, public and cargo transportation, and commercial activities, especially food production. In the second period (after the 1950s), expansion of the city occurred due to the so-called Brazilian economic miracle and the main human activities were industrialization and urbanization processes, involving deforestation, paving, sewage discharge, and petroleum combustion.

The Normal Lung Index From Quantitative Computed Tomography for the Evaluation of Obstructive and Restrictive Lung Disease.

PURPOSE: Our objective was to evaluate whether the normal lung index (NLI) from quantitative computed tomography (QCT) analysis can be used to predict mortality as well as pulmonary function tests (PFTs) in patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). MATERIALS AND METHODS: Normal subjects (n=20) and patients with COPD (n=172) and ILD (n=114) who underwent PFTs and chest CT were enrolled retrospectively in this study. QCT measures included the NLI, defined as the ratio of the lung with attenuation between -950 and -700 Hounsfield units (HU) over the total lung volume (-1024 to -250 HU, mL), high-attenuation area (-700 to -250 HU, %), emphysema index (>6% of pixels < -950 HU), skewness, kurtosis, and mean lung attenuation. Coefficients of correlation between QCT measurements and PFT results in all subjects were calculated. Univariate and multivariate survival analyses were performed to assess mortality prediction by disease. RESULTS: The Pearson correlation analysis showed that the NLI correlated moderately with the forced expiratory volume in 1 second in subjects with COPD (r=0.490, P<0.001) and the forced vital capacity in subjects with ILD (r=0.452, P<0.001). Multivariate analysis revealed that the NLI of <70% was a significant independent predictor of mortality in subjects with COPD (hazard ratio=3.14, P=0.034) and ILD (hazard ratio=2.72, P=0.005). CONCLUSION: QCT analysis, specifically the NLI, can also be used to predict mortality in individuals with COPD and ILD.

Stigmas of congenital Zika syndrome: family perspectives.

This article uses a socio-anthropological framework to explore the stigmas around interactions with children born with congenital Zika syndrome caused by the Zika virus epidemic in two Brazilian municipalities. Semi-structured interviews were conducted with parents and other relatives. We reflected on the search for meaning when having a baby with unexpected body marks, the moral suffering, the societal ableism, the burden of care, and the need for support networks. We concluded that public policies, especially social policies (health, education, and social assistance), are essential for compensatory mechanisms, recognition, and social inclusion of these children and their families.

Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis".

Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin+ astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.

Stigmas of congenital Zika syndrome: family perspectives / Estigmas da síndrome da Zika congênita: perspectivas das famílias / Estigmas del síndrome Zika congénito: perspectivas familiares

This article uses a socio-anthropological framework to explore the stigmas around interactions with children born with congenital Zika syndrome caused by the Zika virus epidemic in two Brazilian municipalities. Semi-structured interviews were conducted with parents and other relatives. We reflected on the search for meaning when having a baby with unexpected body marks, the moral suffering, the societal ableism, the burden of care, and the need for support networks. We concluded that public policies, especially social policies (health, education, and social assistance), are essential for compensatory mechanisms, recognition, and social inclusion of these children and their families.

O artigo adota um referencial socioantropológico para explorar os estigmas subjacentes às interações com crianças que nascem com a síndrome congênita do vírus Zika provocada pela epidemia de Zika em duas cidades brasileiras. Foram realizadas entrevistas semiestruturadas com os pais e outros familiares. Os autores refletem sobre a busca de sentido ao ter um filho com marcas corporais inesperadas, sofrimento moral, capacitismo, o fardo pesado dos cuidados e a necessidade de redes de apoio. Concluem que políticas públicas, principalmente sociais (saúde, educação e assistência social) são essenciais para produzir mecanismos compensatórios, reconhecimento e inclusão social dessas crianças e de suas famílias.

Este artículo adopta un marco socioantropológico para investigar los estigmas subyacentes a las interacciones con niños, nacidos con el síndrome congénito del virus Zika, causado por la epidemia de Zika en dos ciudades brasileñas. Se realizaron entrevistas semiestructuradas con padres y otros parientes. Reflejamos en la investigación el significado de tener un bebé con marcas corporales inesperadas, sufrimiento moral, razón de la discapacidad social y carga de cuidado, así como la necesidad de redes de apoyo. Concluimos que las políticas públicas, especialmente las políticas sociales (salud, educación, y asistencia social), son cruciales produciendo mecanismos compensatorios, reconocimiento e inclusión social de estos niños y sus familias.

Survival analysis of patients with breast cancer and secondary brain metastasis: a retrospective cohort

Introduction: The presence of brain metastases secondary to primary breast cancer implies a worse prognosis for those affected. Therefore, the aim of this study was to determine the median survival after the diagnosis of brain metastasis in patients with breast carcinoma in a center in northeastern Brazil. Methods: The medical records of 345 patients diagnosed with breast cancer, treated between 1998 and July 2018, were analyzed. Those with brain metastasis along with their treatment performed and survival were identified. Results: Nine (2.6%) patients had brain metastasis; the mean age was 56.8 years. The mean survival time determined by the Kaplan-Meier method was 23.8 months (95%CI 6.9­40.8). Seven patients (78%) died from the disease and two were lost to follow-up (22%); invasive carcinoma of no special type was the most frequent (78%). Molecular classification by immunohistochemistry was possible in seven patients: five luminal B subtype cases, one luminal A case and one triple-negative case; luminal B subtype was associated with longer survival: 23.3 months (95%CI 3.0­43.6). As for the initial clinical staging, according to the TNM Classification of Malignant Tumors, there was one IA case, one IIA case, three IIB cases and two IIIB cases. Three patients underwent modified radical mastectomy, and six underwent conservative treatment (quadrantectomy); there was no statistical difference in survival between the different forms of treatment (p=0.771). Conclusion: The median survival after diagnosis of brain metastasis from breast cancer was 23.80 months.

Aids e prevenção: um olhar retrospectivo sobre projetos sociais com jovens no Rio de Janeiro / AIDS and prevention: a retrospective view at social projects with young people in Rio de Janeiro

RESUMO Desde 2010, vem-se observando um desmonte de políticas na área da saúde e dos direitos sexuais e reprodutivos. Este artigo objetivou recuperar a memória de intervenções sociais voltadas para o enfrentamento do HIV/Aids. Para tanto, analisou dois projetos sociais com jovens, desenvolvidos por organizações governamentais e não governamentais, na década de 2000, na favela da Maré, no Rio de Janeiro. Trata-se de um estudo socioantropológico que envolveu análise documental e entrevistas com as coordenadoras dos projetos, visando identificar princípios norteadores, abordagens metodológicas e lições. Os achados indicam que o trabalho de prevenção ao HIV/Aids considerou as demandas dos(as) jovens e abordou, de forma participativa, concepções sobre direitos, sexualidade, gênero e vulnerabilidade. O estímulo à atuação juvenil na produção de intervenções e as parcerias institucionais resultaram em atividades sobre temas do cotidiano vinculados, direta ou indiretamente, à prevenção ao HIV. Tal enfoque se contrapõe aos modelos de ação preconcebidos, muitas vezes impostos em contextos de vulnerabilidade social. Os projetos não estiveram isentos de tensões nas relações adulto vs jovens. Todavia, os desafios foram narrados a partir de uma perspectiva de aprendizagem, indicando a importância da recuperação da experiência pela memória, que ajuda a identificar lições aprendidas e a orientar ações futuras.

ABSTRACT Since 2010, there has been a dismantling of sexual and reproductive health and rights. This article aims to recover the memory of social interventions aimed at fighting HIV/AIDS. To this end, it analyzes two social projects with young people, developed by governmental and non-governmental organizations in the 2000s, in the favela of Maré, in Rio de Janeiro. It is a socio-anthropological study that involved desk review and interviews with the project coordinators, aiming to identify guiding principles, methodological approaches, and lessons. The findings indicate that the HIV/AIDS prevention work considered the demands of young people and addressed, in a participatory way, conceptions on rights, sexuality, gender, and vulnerability. The stimulation of youth activities in the production of interventions and institutional partnerships resulted in activities on everyday topics linked, directly or indirectly, to HIV prevention. This approach is opposed to preconceived models of action, often imposed in contexts of social vulnerability. The projects were not exempt from tensions in adult vs. youth relationships. However, the challenges were narrated from a learning perspective, indicating the importance of retrieving the experience through memory, which helps to identify lessons learned and guide future actions.